Peroxynitrite induces senescence and apoptosis of red blood cells through the activation of aspartyl and cysteinyl proteases Paola Matarrese * , 1 , Elisabetta Straface * , 1 , Donatella Pietraforte † , Lucrezia Gambardella * , Rosa Vona * , Alessandro Maccaglia † , Maurizio Minetti † and Walter Malorni * ,2 Departments of * Drug Research and Evaluation and † Cell Biology and Neurosciences, Istituto Superiore di Sanita’, Rome, Italy 2 Correspondence: Department of Drug Research and Evaluation, Section of Cell Aging and Degeneration, Istituto Superiore di Sanita’, Viale Regina Elena 299, Rome 00161, Italy. E-mail: malorni@iss.it <h3>SPECIFIC AIMS</h3> Erythrocytes are "simplified" cells that, having undergone oxidative imbalance, are committed to senescence and finally to their own destruction. Red blood cells (RBC) from patients with different redox-associated pathologies have been analyzed from functional, structural, or biochemical points of view. The aim was to correlate oxidative changes occurring in RBC with the pathogenesis of certain human diseases and eventually identify specific cellular markers of degeneration. The importance of redox-induced changes in RBC integrity and function is recognized as a pathogenic mechanism of some acquired and genetic diseases, especially surface molecules associated with the clearance of senescent RBC.
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Peroxynitrite induces senescence and apoptosis of red blood cells through the activation of aspartyl and cysteinyl proteases
Matarrese, Paola; Straface, Elisabetta; Pietraforte, Donatella; Gambardella, Lucrezia; Vona, Rosa; Maccaglia, Alessandro; Minetti, Maurizio; Malorni, Walter
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, Volume 19 (3): 416
Fed of American Socs for Experimental Biology – Mar 1, 2005
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