PAX6 expression identifies progenitor cells for corneal keratocytes Martha L. Funderburgh, Yiqin Du, Mary M. Mann, Nirmala SundarRaj and James L. Funderburgh 1 Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 1 Correspondence: Eye and Ear Institute, Rm. 1009, 203 Lothrop St., Pittsburgh, PA 15213, USA. E-mail: jlfunder@pitt.edu <h3>SPECIFIC AIM</h3> The corneal stroma is populated by keratocytes, specialized cells responsible for biosynthesis of the unique transparent connective tissue of the cornea. Keratocytes have a limited ability to replicate without loss of their differentiated phenotype. Both in vivo and in vitro, dividing keratocytes become fibroblastic, secreting nontransparent fibrotic extracellular matrix. The hypothesis of this study was that cornea, like many other adult tissues, contains a population of progenitor cells capable of giving rise to differentiated keratocytes even after extensive proliferation. The data presented here identify and characterize a unique population of cells in adult corneal stroma capable of extensive proliferation in vitro and generation of keratocyte daughter cells. This population is characterized by expression of a number of genes associated with stem cells, as well as PAX6, a homeobox gene expressed during ocular development. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Clonogenic cells in cornea</h3> One characteristic of stem and progenitor cells
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PAX6 expression identifies progenitor cells for corneal keratocytes
Funderburgh, Martha L.; Du, Yiqin; Mann, Mary M.; SundarRaj, Nirmala; Funderburgh, James L.
Follow The FASEB Journal
, Volume 19 (10): 1371
Fed of American Socs for Experimental Biology – Aug 1, 2005
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