Patterns of cell death triggered in two different cell lines by HypF-N prefibrillar aggregates Monica Bucciantini * , 1 , Stefania Rigacci * , 1 , Andrea Berti * , Laura Pieri * , Cristina Cecchi * , Daniele Nosi † , Lucia Formigli † , Fabrizio Chiti * and Massimo Stefani * ,‡ ,2 * Department of Biochemical Sciences, † Department of Anatomy, Histology and Forensic Medicine, ‡ Center of Excellence for Molecular and Clinical Studies on Chronic, Inflammatory, Degenerative and Tumoural Diseases for the Development of New Therapies, University of Florence, Florence, Italy 2 Correspondence: Viale Morgagni 50, Florence 50134, Italy. E-mail: stefani@scibio.unifi.it <h3>SPECIFIC AIMS</h3> We have previously reported that prefibrillar aggregates, but not mature fibrils of a protein unrelated with any disease, the N-terminal domain of the hydrogenase maturation factor HypF (HypF-N), are able to enter into NIH/3T3 cells after incubation in the culture medium. As a consequence, cells display impaired viability due to early modifications of basic biochemical parameters such as intracellular redox status and free Ca 2+ . In this paper, we have investigated the biochemical features of cell death upon exposure to HypF-N toxic prefibrillar aggregates using H-END and NIH/3T3 previously shown
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Patterns of cell death triggered in two different cell lines by HypF-N prefibrillar aggregates
Bucciantini, Monica; Rigacci, Stefania; Berti, Andrea; Pieri, Laura; Cecchi, Cristina; Nosi, Daniele; Formigli, Lucia; Chiti, Fabrizio; Stefani, Massimo
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, Volume 19 (3): 437
Fed of American Socs for Experimental Biology – Mar 1, 2005
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