Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines 1 DAVID B. CORRY * ,† ,‡ , ATTILA KISS * , LI-ZHEN SONG * , LING SONG * , JIE XU * , SEUNG-HYO LEE * ,† , ZENA WERB § and FARRAH KHERADMAND * ,† ,2 Departments of * Medicine and † Immunology, and ‡ Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA; and § Department of Anatomy, University of California, San Francisco, California, USA 2 Correspondence: Baylor College of Medicine, One Baylor Plaza, Suite 520B, Houston, TX 77030, USA. E-mail: farrahk@bcm.tmc.edu <h3>SPECIFIC AIMS</h3> Mechanisms that initiate allergic lung inflammation are relevant to expression of diseases such as asthma, but the factors underlying resolution of inflammation are equally important. Immune cells recruited to sites of allergic inflammation express MMP9, but the physiological role of this enzyme in allergic lung disease remains unclear. We hypothesized that, much like MMP2, the closely related protease MMP9 may play an important role in facilitating the clearance of preapoptotic inflammatory cells in the allergic lung. <h3>PRINCIPAL FINDINGS</h3> <h3>1. MMP9 is expressed by recruited leukocytes during allergic lung
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Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines
CORRY, DAVID B.; KISS, ATTILA; SONG, LI-ZHEN; SONG, LING; XU, JIE; LEE, SEUNG-HYO; WERB, ZENA; KHERADMAND, FARRAH
Follow The FASEB Journal
, Volume 18 (9): 995
Fed of American Socs for Experimental Biology – Jun 1, 2004
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