Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-related muscle dysfunction ANNE McARDLE * ,2 , WOLFGANG H. DILLMANN † , RUBEN MESTRIL ‡ , JOHN A. FAULKNER § and MALCOLM J. JACKSON * * Department of Medicine, University of Liverpool, Liverpool, UK; † Department of Medicine, University of California, San Diego, California, USA; ‡ Department of Physiology, Loyola University, Chicago, Illinois, USA; and § Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA 2 Correspondence: Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK. E-mail: mdcr02@liv.ac.uk <h3>SPECIFIC AIMS</h3> Skeletal muscle aging is characterized by atrophy, a deficit in the generation of specific force, increased susceptibility to contraction-induced injury, and a prolonged force deficit after severe injury. The ability of muscles of old mice to produce HSPs in response to stress is severely diminished. The aim of this study was to examine the effect of overexpression of HSP70 on these functional deficits after a severe and damaging protocol of lengthening contractions in adult and old mice. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Transgenic overexpression of HSP70 in skeletal muscle protects against lengthening contraction-induced damage and facilitates rapid and successful recovery after damage</h3> The investigation involved
End of preview. The entire article is 3 pages. To view the full-text, please rent this article to continue.
/lp/fed-of-american-socs-for-experimental-biology/overexpression-of-hsp70-in-mouse-skeletal-muscle-protects-against-OYmJ1vs0Q0
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-related muscle dysfunction
McARDLE, ANNE; DILLMANN, WOLFGANG H.; MESTRIL, RUBEN; FAULKNER, JOHN A.; JACKSON, MALCOLM J.
Follow The FASEB Journal
, Volume 18 (2): 355
Fed of American Socs for Experimental Biology – Feb 1, 2004
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
