Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: in vitro and in vivo study Yoon Jeong Park * ,1 , Li-Chien Chang † , Jun Feng Liang ‡ , Cheol Moon || , Chong-Pyoung Chung § and Victor C. Yang || * Craniomaxillofacial Reconstructive Science Major, School of Dentistry and Intellectual Biointerface Engineering Center, Seoul National University, Seoul, South Korea; † School of Pharmacy, National Defense Medical Center, Taipei, Taiwan; ‡ Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey, USA; § Department of Periodontology, School of Dentistry and Intellectual Biointerface Engineering Center, Seoul National University, Seoul, South Korea; and || College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, USA 1 Correspondence: School of Dentistry and Intellectual Biointerface Engineering Center, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea. E-mail: parkyj@snu.ac.kr <h3>SPECIFIC AIM</h3> The aim of this study is to demonstrate the feasibility of naturally derived low molecular weight protamine as a potential translocational domain for the intracellular delivery of molecular medicine including macromolecular drug (i.e., protein), therapeutic gene, or molecular diagnostic probes as well as nanoparticulates. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Preparation of the
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Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: in vitro and in vivo study
Park, Yoon Jeong; Chang, Li-Chien; Liang, Jun Feng; Moon, Cheol; Chung, Chong-Pyoung; Yang, Victor C.
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, Volume 19 (11): 1555
Fed of American Socs for Experimental Biology – Sep 1, 2005
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