Non-human primates (NHP) are essential translational models for biomedical research. Dendritic cells (DC) are a group of antigen presenting cells (APC) that play pivotal roles in the immunobiology of health and disease and are attractive cells for adoptive immunotherapy to stimulate and suppress immunity. DC have been studied extensively in humans and mice but until recently, have not been well characterized in NHP. This review considers the available data about DC across a range of NHP species and summarizes the understanding of in vitro-propagated DC and in vivo-isolated DC, which is now established. It is clear that although NHP DC exist within the paradigm of human DC, there are important functional and phenotypic differences when compared with human DC subsets. These differences need to be taken into account when designing preclinical, translational studies of DC therapy using NHP models. in vitro propagation growth factor mobilization immunotherapy translational research Footnotes APC antigen presenting cell or cells BDCA blood DC antigen BM bone marrow CD40L CD40 ligand CFSE carboxyfluorescein succinimidyl ester DC dendritic cell or cells DC-SIGN DC-specific ICAM-3-grabbing nonintegrin Flt3-L fms-like tyrosine kinase 3 ligand FoxP3 forkhead box protein 3 G-CSF granulocyte colony stimulating factor GM-CSF granulocyte-macrophage colony stimulating factor HSV herpes simplex virus IFN interferon Lin – lineage-negative LN lymph node LPS lipopolysaccharide mAb monoclonal antibody MCM monocyte-conditioned medium mDC myeloid DC MHC major histocompatibility complex MLR mixed lymphocyte reaction MNC mononuclear cell MoDC monocyte-derived DC NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells NHP non-human primate or primates NWP New World primate OWP Old World primate PBMC peripheral blood mononuclear cell pDC plasmacytoid DC PGE 2 prostaglandin E 2 pre-DC DC precursor poly I:C polyinosinic:polycytidylic acid PGE 2 prostaglandin E2 ProGP progenipoietin SCF stem cell factor TLR toll-like receptor TNF tumor necrosis factor TPO thrombopoietin Treg regulatory T cell Received July 17, 2011. Revision received October 11, 2011. Accepted October 14, 2011. © 2012 Society for Leukocyte Biology Facebook Google+ LinkedIn Mendeley Reddit StumbleUpon Technorati Twitter What's this? « Previous | Next Article » Table of Contents This Article Published online before print November 28, 2011 , doi: 10.1189/jlb.0711355 February 2012 Journal of Leukocyte Biology vol. 91 no. 2 217-228 » Abstract Full Text Full Text (PDF) All Versions of this Article: jlb.0711355v1 91/2/217 most recent Classifications Reviews Services Email this article to a colleague Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Google Scholar Articles by Jesudason, S. Articles by Coates, P. T. H. PubMed PubMed citation Articles by Jesudason, S. Articles by Coates, P. T. H. Related Content Load related web page information Sharing Email this article to a colleague Facebook Google+ LinkedIn Mendeley Reddit StumbleUpon Technorati Twitter What's this? Current Issue February 2012, 91 (2) From the Cover Editorials: Tim-3 puts on the brakes. Editorials: T cell memory, bone marrow, and aging: the good news. Spotlight on Leading Edge Research: Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes. Spotlight on Leading Edge Research: The impact of aging on memory T cell phenotype and function in the human bone marrow. Reviews: Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation. Reviews: Non-human primate dendritic cells. Alert me to new issues of Journal of Leukocyte Biology About JLB Submit Manuscripts Instructions for Authors Information for Reviewers Editorial Board Editorial Policies Subscriptions Librarian's Resource Advertising Press Room Copyright Permissions Feedback Join SLB SLB Annual Meeting Copyright © 2012 by the Society for Leukocyte Biology Print ISSN: 0741-5400 Online ISSN: 1938-3673 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-23108860-1"); pageTracker._trackPageview();

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