MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle Willem J. M. Mulder * ,1 , Gustav J. Strijkers, Jo W. Habets * , Egbert J. W. Bleeker * , Daisy W.J. van der Schaft # , Gert Storm † , Gerben A. Koning † ,¶ , Arjan W. Griffioen # and Klaas Nicolay * * Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, MB Eindhoven, The Netherlands; # Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology/Internal Medicine, Maastricht University & University Hospital, AZ Maastricht, The Netherlands; † Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, The Netherlands; and ¶ Department of Radiation, Radioisotopes, and Reactors, Faculty of Applied Sciences, Delft University of Technology, JB Delft, The Netherlands 1 Correspondence: Biomedical NMR, Dept of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. E-mail: w.j.m.mulder@tue.nl <h3>SPECIFIC AIMS</h3> The first aim of the present study was to assess whether MR molecular imaging of angiogenesis is possible using αvβ3-specific bimodal lipidic nanoparticles (LNP) in tumor-bearing mice. The second aim was to unravel the mechanism and site of accumulation of the
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MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
Mulder, Willem J. M.; Strijkers, Gustav J.; Habets, Jo W.; Bleeker, Egbert J. W.; van der Schaft, Daisy W.J.; Storm, Gert; Koning, Gerben A.; Griffioen, Arjan W.; Nicolay, Klaas
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, Volume 19 (14): 2008
Fed of American Socs for Experimental Biology – Dec 1, 2005
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