Mouse intestinal cryptdins exhibit circadian oscillation Oren Froy * ,1 , Nava Chapnik * and Ruth Miskin † * Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel; and † Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel 1 Correspondence: E-mail: froy@agri.huji.ac.il <h3>SPECIFIC AIMS</h3> The goal of this study was to determine whether the biological clock plays a role in cryptdin expression under healthy conditions. <h3>PRINCIPAL FINDINGS</h3> <h3>1. FVB/N mice exhibit molecular oscillation of clock genes</h3> To study mouse cryptdin regulation by the biological clock, we first verified that FVB/N mice displayed a functional clock. Although FVB/N mice exhibit physiological circadian rhythms, this strain was shown to display a fragmented wheel-running activity pattern with increased activity during the light phase compared with other mouse strains. Therefore, we first wanted to establish that FVB/N mice displayed a functional biological clock at the molecular levels. Mice were maintained at 12 h light and 12 h dark (LD) conditions for two weeks for their biological clocks to entrain. After two weeks, the expression of two liver clock genes, mPer1 and mBmal1 (data not shown), was determined
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Mouse intestinal cryptdins exhibit circadian oscillation
Froy, Oren; Chapnik, Nava; Miskin, Ruth
Follow The FASEB Journal
, Volume 19 (13): 1920
Fed of American Socs for Experimental Biology – Nov 1, 2005
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