Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty Saravana Mohan Dhanasekaran * , 1 , Atreya Dash † , 1 , Jianjun Yu * , 1 , Ira P. Maine * , Bharathi Laxman * , Scott A. Tomlins * , Chad J. Creighton ‡ , Anjana Menon * , Mark A. Rubin § and Arul M. Chinnaiyan * ,† ,‡ ,2 * Department of Pathology, † Michigan Urology Center, ‡ Bioinformatics Program, University of Michigan Medical School, Ann Arbor, Michigan, USA; and § Department of Pathology, Brigham and Women’s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA 2 Correspondence: Department of Pathology and Urology, University of Michigan Medical School, 1301 Catherine Rd., MSI Rm. 4237, Ann Arbor, MI 48109-0602, USA. E-mail: arul@umich.edu <h3>SPECIFIC AIMS</h3> Our aim was to identify gene expression changes occurring in the human prostate gland at puberty, a crucial juncture in prostate development that is androgen dependent, and to thereby identify novel in vivo targets of androgen action. <h3>PRINCIPAL FINDINGS</h3> Prostate tissues obtained from cadaveric organ donors were grouped into two categories: the pubertal group comprised individuals from 9 to 13 years
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Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty
Dhanasekaran, Saravana Mohan; Dash, Atreya; Yu, Jianjun; Maine, Ira P.; Laxman, Bharathi; Tomlins, Scott A.; Creighton, Chad J.; Menon, Anjana; Rubin, Mark A.; Chinnaiyan, Arul M.
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, Volume 19 (2): 243
Fed of American Socs for Experimental Biology – Feb 1, 2005
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