Microglia provide neuroprotection after ischemia Jens Neumann † , Matthias Gunzer || , Herwig O. Gutzeit § , Oliver Ullrich ‡ , Klaus G. Reymann * ,† and Klaus Dinkel † ,1 * Leibniz Institute for Neurobiology, Project Group Neuropharmacology, Magdeburg, Germany; † Institute for Applied Neuroscience (FAN gGmbH), Magdeburg, Germany; ‡ Institute of Immunology, University Hospital Magdeburg, Magdeburg, Germany; § Institute of Zoology, Technical University Dresden, Dresden, Germany; and || German Research Centre for Biotechnology, Research Group Immunodynamics, Braunschweig, Germany 1 Correspondence: Jerini AG, Invalidenstr. 130, Berlin 10115, Germany. E-mail: dinkel@jerini.com <h3>SPECIFIC AIMS</h3> Ischemic injury (stroke) represents the third leading cause of death in the developed countries. Yet the associated mechanisms and especially the role of post-stroke neuroinflammation are still poorly understood. Our aim was to elucidate the highly debated (harmful or beneficial) role of microglia in the context of an ischemic insult. Our unique experimental design includes the exogenous application of fluorescently labeled microglial cell line BV2 to transgenic (fluorescently labeled neurons) organotypic hippocampal cultures. We could thus modify microglia prior to application, reach pathophysiologically relevant microglia numbers, and ensure that the observed effects were mediated exclusively by the microglia. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Microglia protect against
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Microglia provide neuroprotection after ischemia
Neumann, Jens; Gunzer, Matthias; Gutzeit, Herwig O.; Ullrich, Oliver; Reymann, Klaus G.; Dinkel, Klaus
Follow The FASEB Journal
, Volume 20 (6): 714
Fed of American Socs for Experimental Biology – Apr 1, 2006
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