Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-κB and Akt as targets Adriana Albini * , Raffaella Dell’Eva * , Roberta Vené * , Nicoletta Ferrari * , Donald R. Buhler † , Douglas M. Noonan ‡ ,1 and Gianfranco Fassina § ,|| * Molecular Oncology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy; † Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA; ‡ Dipartimento di Scienze Cliniche e Biologiche, Universita' degli Studi dell'Insubria, Varese, Italy; § Tumor Progression Unit, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy; and || Istituto di Bioimmagini e Fisiologia Molecolare, Sezione di Genova, Consiglio Nazionale delle Ricerche, Genoa, Italy 1 Correspondence: Facoltà di Medicina e Chirurgia, Dipartimento di Scienze Cliniche e Biologiche, Universita' degli Studi dell'Insubria, Via Ottorino Rossi 9, Varese 21100, Italy. E-mail: douglas.noonan@uninsubria.it <h3>SPECIFIC AIMS</h3> Xanthohumol (XN) is a flavonoid of the chalcone chemical class isolated from hop ‘cones’, the female inflorescences of the hop plant ( Humulus lupulus L.). It is largely used in the brewing industry as a preservative and flavoring agent. Several natural compounds of plant origin and dietary components, have been shown to have cancer chemoprevention
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Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-κB and Akt as targets
Albini, Adriana; DellEva, Raffaella; Vené, Roberta; Ferrari, Nicoletta; Buhler, Donald R.; Noonan, Douglas M.; Fassina, Gianfranco
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, Volume 20 (3): 527
Fed of American Socs for Experimental Biology – Mar 1, 2006
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