Maspin alters the carcinoma proteome Emily I. Chen ‡ ,1 , Laurence Florens ‡ , 2 , Fumiko T. Axelrod § , Edward Monosov § , Carlos F. Barbas, III † , John R. Yates, III ‡ , Brunhilde Felding-Habermann * and Jeffrey W. Smith § * Department of Molecular and Experimental Medicine, † Department of Molecular Biology and ‡ Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA; and § The Cancer Research Center, Program on Cell Adhesion at The Burnham Institute, La Jolla, California, USA 1 Correspondence: Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA. E-mail: emilyc@scripps.edu <h3>SPECIFIC AIMS</h3> The aims of this study were: 1) to apply a sophisticated shot-gun proteomic method (MudPIT) to carry out the proteome analysis of breast cancer cells with or without the metastatic tumor suppressor gene maspin; and 2) to generate a mechanistic hypothesis of maspin’s role in tumor metastasis based on the observed proteome modification. <h3>PRINCIPAL FINDINGS</h3> <h3>1. A large scale proteome analysis of metastatic breast cancer cells and of the changes that took place by restoring maspin expression was conducted</h3> <h3>2. Three metastasis-related protein networks
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Maspin alters the carcinoma proteome
Chen, Emily I.; Florens, Laurence; Axelrod, Fumiko T.; Monosov, Edward; Barbas, Carlos F.; Yates, John R.; Felding-Habermann, Brunhilde; Smith, Jeffrey W.
Follow The FASEB Journal
, Volume 19 (9): 1123
Fed of American Socs for Experimental Biology – Jul 1, 2005
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