Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARα in fasting mice 1 ERDAL EROL * , 2 , LEENA S. KUMAR * , 2 , GARY W. CLINE † , GERALD I. SHULMAN † , DANIEL P. KELLY ‡ and BERT BINAS * ,3 * Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA; † Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, USA; and ‡ Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri, USA 3 Correspondence: Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, Raymond Stotzer Pkwy, College Station, TX 77843-4467, USA. E-mail: bbinas@cvm.tamu.edu <h3>SPECIFIC AIMS</h3> 1. Liver fatty acid binding protein (L-FABP) is the main cytosolic binding site for long chain fatty acids (LCFA) in hepatocytes. Here we elucidated the significance of L-FABP for hepatic fatty acid oxidation in vivo. 2. In cell culture, L-FABP has been shown to increase activity and levels of peroxisome proliferator-activated receptor α (PPARα), a transcription factor that boosts hepatic fatty acid oxidation and ketogenesis. We tested
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Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARα in fasting mice
EROL, ERDAL; KUMAR, LEENA S.; CLINE, GARY W.; SHULMAN, GERALD I.; KELLY, DANIEL P.; BINAS, BERT
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, Volume 18 (2): 347
Fed of American Socs for Experimental Biology – Feb 1, 2004
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