Lipocalin 2 functions as a negative regulator of red blood cell production in an autocrine fashion Ken-ichi Miharada * ,† , Takashi Hiroyama * , Kazuhiro Sudo * , Toshiro Nagasawa † and Yukio Nakamura * ,1 * Cell Engineering Division, BioResource Center, RIKEN, Tsukuba, Ibaraki, Japan; and † Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan 1 Correspondence: Cell Engineering Division, BioResource Center, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan. E-mail: yukionak@brc.riken.jp <h3>SPECIFIC AIMS</h3> Members of the lipocalin protein family are typically small, secreted proteins that possess a variety of functions, including the regulation of the immune response and the mediation of cell homeostasis. Although the physiological role of lipocalin 2 remains to be fully elucidated, a few pivotal functions have recently been reported. These functions include regulation of the apoptosis of leukocytes, the transport of iron, and inhibition of bacterial growth by sequestration of the iron-laden siderophore. Initially, we unexpectedly found that lipocalin 2 is abundantly expressed in erythroid progenitor cells, progenitors of red blood cells (RBCs). To delineate the roles of lipocalin 2 in erythropoiesis, we assessed the functions of lipocalin 2 in the in vitro and in vivo models
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Lipocalin 2 functions as a negative regulator of red blood cell production in an autocrine fashion
Miharada, Ken-ichi; Hiroyama, Takashi; Sudo, Kazuhiro; Nagasawa, Toshiro; Nakamura, Yukio
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, Volume 19 (13): 1881
Fed of American Socs for Experimental Biology – Nov 1, 2005
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