Intracellular Aß42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer’s disease Yasumasa Ohyagi * ,1 , Hideaki Asahara * , De-Hua Chui † , Yuko Tsuruta * , Nobutaka Sakae * , Katsue Miyoshi * , Takeshi Yamada * , Hitoshi Kikuchi * , Takayuki Taniwaki * , Hiroyuki Murai * , Koji Ikezoe * , Hirokazu Furuya * , Takeshi Kawarabayashi ‡ , Mikio Shoji ‡ , Frederic Checler§, Toru Iwaki || , , Takao Makifuchi †† , Kazuya Takeda ‡‡ , Jun-ichi Kira * and Takeshi Tabira ‡‡ * Department of Neurology, || Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; † Division of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan; ‡ Department of Neurology, Neuroscience, Biophysiological Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan; || Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France; †† Department of Clinical Research, National Saigata Hospital, Niigata, Japan; and ‡‡ National Institute for Longevity Sciences, Aichi, Japan 1 Correspondence: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: ohyagi@neuro.med.kyushu-u.ac.jp <h3>SPECIFIC AIMS</h3> Alzheimer’s disease (AD) is the
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