Insulin resistance of muscle protein metabolism in aging Blake B. Rasmussen * ,† , Satoshi Fujita ‡ , Robert R. Wolfe || , Bettina Mittendorfer || , Mona Roy ‡ , Vincent L. Rowe § and Elena Volpi ‡ ,1 Departments of * Kinesiology, † Biological Sciences, ‡ Medicine, and § Surgery, University of Southern California, Los Angeles, California, USA; and || Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA 1 Correspondence: Department of Internal Medicine, Division of Geriatric Medicine, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0460, USA. E-mail: evolpi@utmb.edu <h3>SPECIFIC AIMS</h3> We hypothesized that skeletal muscle protein synthesis in the elderly is resistant to the anabolic action of insulin, and that this effect of aging is independent of a normal glucose tolerance. To test this hypothesis, we exposed the muscles of one leg to hyperinsulinemia by infusing insulin in the femoral artery (with a euglycemic clamp as necessary) and measured muscle amino acid and protein turnover with stable isotope methodologies in older and younger healthy, glucose tolerant subjects. This study design prevented the large decrease in blood amino acid concentrations commonly seen with systemic insulin infusion and allowed us to
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Insulin resistance of muscle protein metabolism in aging
Rasmussen, Blake B.; Fujita, Satoshi; Wolfe, Robert R.; Mittendorfer, Bettina; Roy, Mona; Rowe, Vincent L.; Volpi, Elena
Follow The FASEB Journal
, Volume 20 (6): 768
Fed of American Socs for Experimental Biology – Apr 1, 2006
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