Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation Erik Kwidzinski * ,1 , Jörg Bunse * , Orhan Aktas † , Daniel Richter * , Leman Mutlu * , Frauke Zipp † , Robert Nitsch * and Ingo Bechmann * * Center for Anatomy, Institute of Cell Biology and Neurobiology, Charité University Hospital Berlin; and † Institute of Neuroimmunology, Clinical and Experimental Neuroimmunology, Charité University Hospital Berlin, Germany 1 Correspondence: E-mail: erik.kwidzinski@charite.de <h3>SPECIFIC AIMS</h3> The mechanisms of spontaneous recovery from autoimmune central nervous system (CNS) inflammation in multiple sclerosis (MS) and its animal model autoimmune encephalomyelitis (EAE) remain poorly understood. One requirement for recovery from EAE is the control over self-reactive T cells from the CNS and the periphery. The tryptophan (trp)-degrading enzyme IDO is the first and rate-limiting enzyme of the kynurenine pathway. IDO activation reduces T cell proliferation and susceptibility to CD95L-induced apoptosis due to tryptophan depletion and the production of T cell-toxic tryptophan metabolites such as 3-hydrocyanthranilic acid and quinolic acid. Therefore, the primary aim of our work was to determine whether IDO is expressed and active within the CNS during autoimmune inflammation in EAE-induced SJL mice. To assess time-dependent IDO activity
End of preview. The entire article is 3 pages. To view the full-text, please rent this article to continue.
/lp/fed-of-american-socs-for-experimental-biology/indolamine-2-3-dioxygenase-is-expressed-in-the-cns-and-down-regulates-KZQR1srzG0
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation
Kwidzinski, Erik; Bunse, Jörg; Aktas, Orhan; Richter, Daniel; Mutlu, Leman; Zipp, Frauke; Nitsch, Robert; Bechmann, Ingo
Follow The FASEB Journal
, Volume 19 (10): 1347
Fed of American Socs for Experimental Biology – Aug 1, 2005
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
