In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies 1 ISTVAN PIRKO * , 2 , AARON JOHNSON * ,† , 2 , BOGOLJUB CIRIC † , JEFF GAMEZ * , SLOBODAN I. MACURA ‡ , LARRY R. PEASE † ,‡ and MOSES RODRIGUEZ * ,† ,3 * Departments of Neurology, † Immunology, and ‡ Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota, USA 3 Correspondence: Mayo Clinic and Foundation, 200 First St. SW, Rochester, MN 55905, USA. E-mail: Rodriguez@mayo.edu <h3>SPECIFIC AIMS</h3> We developed an MRI technique to image immune cell location and homing in vivo to the central nervous system (CNS). Superparamagnetic antibodies specific for cell surface markers allowed imaging of CD4+ T cells, CD8+ T cells, and Mac1+ cells in the CNS of mice infected with Theiler’s murine encephalomyelitis virus (TMEV) and in mice with experimental autoimmune encephalomyelitis (EAE). <h3>PRINCIPAL FINDINGS</h3> <h3>1. In vivo MRI detects immune cells in viral and autoimmune models of multiple sclerosis</h3> We evaluated the efficacy of a new method to image immune cells in the CNS of animals chronically infected with TMEV. Superparamagnetic anti-CD4, anti-CD8, anti-Mac1, and irrelevant control anti-human CD19 antibodies
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In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies
PIRKO, ISTVAN; JOHNSON, AARON; CIRIC, BOGOLJUB; GAMEZ, JEFF; MACURA, SLOBODAN I.; PEASE, LARRY R.; RODRIGUEZ, MOSES
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, Volume 18 (1): 179
Fed of American Socs for Experimental Biology – Jan 1, 2004
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