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Journals The FASEB Journal Volume 22 Issue 7

In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer Hiroshi Wakao * ,§ ,1 , Rika Wakao ‡ ,2 , Sakura Sakata § , Kazuya Iwabuchi † , Atsushi Oda * and Hiroyoshi Fujita * * Department of Environmental Biology, School of Medicine, and † Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan; and ‡ Developmental Genetics Group and § Immune Regulation Group, Rikagaku Kenkyusho (RIKEN), Research Center for Allergy and Immunology, Yokohama, Japan 1 Correspondence: Department of Environmental Biology, School of Medicine, Hokkaido University, N15W7, Sapporo 060-8638, Japan. E-mail: hwakao@med.hokudai.ac.jp The ectopic expression of the Notch receptor ligand delta-like 1 on stromal cells allows the induction of T cells from embryonic stem cells (ESCs). However, these in vitro -generated T cells are not transplantable because they are too immature to mount an immune response in an immunocompromised animal. We efficiently generated a subset of T cells called invariant natural killer T ( i NKT) cells from ESCs derived from peripheral i NKT cells using somatic cell nuclear transfer (ntESCs). These i NKT cells matured autonomously in vivo and exhibited an adjuvant effect accompanying the production of interferon-γ in an antigen-specific manner. This adjuvant effect culminated in the inhibition of inoculated tumor cell growth. Our results indicate that ntESC-derived i NKT cells are transplantable lymphocytes that will be beneficial for the induction of immune tolerance and the treatment of autoimmune diseases, tumors, and infections.—Wakao, H., Wakao, R., Sakata, S., Iwabuchi, K., Oda, A., Fujita, H. In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer. Key Words: adjuvant effect • in vitro differentiation • transplantable lymphocytes • tumor rejection

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In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer

Wakao, Hiroshi; Wakao, Rika; Sakata, Sakura; Iwabuchi, Kazuya; Oda, Atsushi; Fujita, Hiroyoshi
The FASEB Journal , Volume 22 (7): 2223
Fed of American Socs for Experimental Biology – Jul 1, 2008

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