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Journals Journal of Leukocyte Biology July 2009

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Impaired M. tuberculosis-mediated apoptosis in alveolar macrophages from HIV+ persons: potential role of IL-10 and BCL-3

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The mechanism of increased MTb disease susceptibility in HIV+ persons remains poorly understood. Apoptosis of macrophages in response to MTb represents a critical host defense response, and decreased apoptosis may represent a mechanism of increased susceptibility to MTb in HIV. In the current study, MTb-mediated apoptosis of human AM was reduced in HIV+ subjects compared with healthy subjects in a TNF- -dependent manner. IL-10 levels in BALF from HIV+ persons were significantly elevated compared with HIV– persons, and exogenous IL-10 reduced MTb-mediated apoptosis in healthy AM, suggesting that IL-10 could mediate decreased apoptosis observed in HIV. Further study showed that IL-10 reduced TNF release in response to MTb in AM through a reduction in TNF mRNA levels, and exogenous TNF could partially reverse IL-10-associated effects on AM apoptosis. IL-10 did not influence p-IRAK, I B degradation, or NF- B p65 nuclear translocation in response to MTb, but IL-10 did increase levels of AM BCL-3, an inhibitor of NF- B nuclear activity. BCL-3 knockdown in human macrophages increased MTb-mediated TNF release. Importantly, BCL-3 levels in AM from HIV+ subjects were higher compared with healthy subjects. Taken together, these data suggest that elevated lung levels of IL-10 may impair MTb-mediated AM apoptosis in HIV through a BCL-3-dependent mechanism. BCL-3 may represent a potential therapeutic target to treat or prevent MTb disease in HIV+ persons. Key Words: Toll-like receptors • molecules • transcription factors • NF- B Related Article Editorial: Live or let die—does HIV exacerbate tuberculosis by attenuating M. tuberculosis -induced apoptosis? Ajit Lalvani and Suzanne Hingley-Wilson J. Leukoc. Biol. 2009 86: 9-11. Full Text PDF

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Article Details
Patel, Naimish R.; Swan, Katharine; Li, Xin; Tachado, Souvenir D.; Koziel, Henry
Journal of Leukocyte Biology , Volume 86 (1): 53
Fed of American Socs for Experimental Biology – Jul 1, 2009
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