Impact of HIF-1α and HIF-2α on proliferation and migration of human pulmonary artery fibroblasts in hypoxia Bastian Eul 1 , Frank Rose 1 , Stefanie Krick, Rajkumar Savai, Parag Goyal, Walter Klepetko * , Friedrich Grimminger, Norbert Weissmann, Werner Seeger and Jörg Hänze 2 University of Giessen Lung Center (UGLC), Medical Clinic II, Justus-Liebig University, Giessen, Germany; and * Cardiothoracic Surgery, University Hospital, Vienna, Austria 2 Correspondence: University of Giessen Lung Center (UGLC), Medical Clinic II, Justus-Liebig University, Klinikstr. 36, D-35392 Giessen, Germany. E-mail: joerg.haenze@uglc.de <h3>SPECIFIC AIMS</h3> Prolonged alveolar hypoxia, as occurs at high altitude, in chronic obstructive pulmonary disease and in various restrictive lung diseases, results in a remodeling of the pulmonary vasculature, which is characterized by proliferative changes in the intima, media, and adventitia of the pulmonary artery. These changes may cause chronic pulmonary arterial hypertension and subsequent cor pulmonale. Several findings indicate that the adventitial layer of the pulmonary arteries is centrally involved in the hypoxia-driven remodeling process. In this study, we investigated the hypothesis that hypoxic adaptive processes are mainly related to the induction of hypoxia-inducible factors (HIF). We followed the aim to analyze relevant cellular adaptive responses in human adventitial fibroblasts in relation
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Impact of HIF-1α and HIF-2α on proliferation and migration of human pulmonary artery fibroblasts in hypoxia
Eul, Bastian; Rose, Frank; Krick, Stefanie; Savai, Rajkumar; Goyal, Parag; Klepetko, Walter; Grimminger, Friedrich; Weissmann, Norbert; Seeger, Werner; Hänze, Jörg
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, Volume 20 (1): 163
Fed of American Socs for Experimental Biology – Jan 1, 2006
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