Hypoxia-induced preconditioning in adult stimulated cardiomyocytes is mediated by the opening and trafficking of sarcolemmal K ATP channels 1 GRANT R. BUDAS, SOFIJA JOVANOVIĆ, RUSSELL M. CRAWFORD and ALEKSANDAR JOVANOVIĆ 2 Maternal and Child Health Sciences, Tayside Institute of Child Health, Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, UK 2 Correspondence: Maternal and Child Health Sciences, Tayside Institute of Child Health, Ninewells Hospital & Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK. E-mail: a.jovanovic@dundee.ac.uk <h3>SPECIFIC AIMS</h3> Sarcolemmal ATP-sensitive K + (K ATP ) channels, composed of Kir6.2 and SUR2A subunits, couple the metabolic status of a cell with membrane excitability. Based on recent studies, we hypothesized that trafficking and activity of sarcolemmal K ATP channels may be involved in mediating preconditioning (brief periods of ischemia/reoxygenation that precede sustained ischemia lead to a reduction in myocardial infarct size) in the heart. We took advantage of a model of preconditioning that uses adult cardiomyocytes stimulated to beat and examined whether activity and trafficking of K ATP channels are involved in the intracellular signaling of preconditioning in the heart. <h3>PRINCIPAL FINDINGS</h3> 1. Hypoxia induces death of cardiomyocytes without affecting levels of sarcolemmal K ATP channel subunits
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Hypoxia-induced preconditioning in adult stimulated cardiomyocytes is mediated by the opening and trafficking of sarcolemmal KATP channels
BUDAS, GRANT R.; JOVANOVIC, SOFIJA; CRAWFORD, RUSSELL M.; JOVANOVIC, ALEKSANDAR
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, Volume 18 (9): 1046
Fed of American Socs for Experimental Biology – Jun 1, 2004
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