Inï¬ammation Research Network, University of Calgary, Calgary, Alberta, Canada ABSTRACT Hydrogen sulï¬de is an endogenous mediator that relaxes vascular smooth muscle, exhibits several antiinï¬ammatory activities, and contributes to gastric mucosal defense. This study was performed to examine the role of hydrogen sulï¬de in the resolution of injury; speciï¬cally, the healing of gastric ulcers. Ulcers were induced in rats by serosal application of acetic acid. This elicited a marked increase in gastric expression of the two key enzymes in hydrogen sulï¬de synthesis (cystathionine-synthase and cystathionine- -lyase) and in hydrogen sulï¬de synthesis. Twice-daily treatment for a week with hydrogen sulï¬de donors signiï¬cantly increased the extent of healing of gastric ulcers as compared to vehicletreatment. Similar treatment with L-cysteine, a precursor for hydrogen sulï¬de, also accelerated healing of the ulcers, and the effect was abolished by cotreatment with an inhibitor of cystathionine- -lyase. The beneï¬cial effects of hydrogen sulï¬de on ulcer healing were not dependent on nitric oxide synthesis, nor did they appear to occur through activation of ATP-sensitive K channels. These results suggest that hydrogen sulï¬de is produced in the gastric mucosa in response to injury and acts to promote healing. The results further suggest that drugs releasing hydrogen sulï¬de
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Hydrogen sulfide enhances ulcer healing in rats
John L. Wallace , Michael Dicay , Webb McKnight , and Gary R. Martin
Follow The FASEB Journal
, Volume 21 (14): 4070
Fed of American Socs for Experimental Biology – Dec 1, 2007
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