Hemopexin: anti-inflammatory, pro-inflammatory, or both? W. W. Bakker 1 , B. N. Melgert and M. M. Faas Department of Pathology and Medical Biology, University Medical Center of Groningen, Groningen, The Netherlands 1. Correspondence: Department of Pathology and Medical Biology, University Medical Center of Groningen, Groningen, The Netherlands. E-mail: w.w.bakker@path.umcg.nl acute-phase reactants inflammation protease Dear Editor, The interesting article of Liang et al. [ 1 ] describes an anti-inflammatory property of Hx, showing down-regulation of LPS-induced secretion of TNF-α and IL-6 from murine bone marrow-derived or peritoneal macrophages in vitro. Commercially obtained human rHx appeared to exhibit the same activity [ 1 ] . In the Editorial of the same issue of this journal, by Mitchell P. Fink [ 2 ] , Hx is called: “…newest member of the anti-inflammatory club.” Indeed, the data of Liang et al. [ 1 ] provide convincing evidence for a novel property of Hx, as in text books or literature reviews up until now, Hx is known exclusively for its heme-scavenging properties, preventing heme-induced oxidant stress [ 3 , 4 ] . However, we have shown previously that purified plasma Hx as well as human rHx have protease activity that can be inhibited
End of preview. The entire article is 2 pages. To view the full-text, please rent this article to continue.
/lp/fed-of-american-socs-for-experimental-biology/hemopexin-anti-inflammatory-pro-inflammatory-or-both-nOmDPDocIo
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Hemopexin: anti-inflammatory, pro-inflammatory, or both?
Bakker, W. W.; Melgert, B. N.; Faas, M. M.
Follow Journal of Leukocyte Biology
, Volume 87 (1): 1
Fed of American Socs for Experimental Biology – Jan 1, 2010
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
