Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells James McDaid * , Kenichiro Yamashita * , Angelo Chora † , Robert Öllinger * , Terry B. Strom ‡ , Xian C. Li ‡ , Fritz H. Bach * , 1 and Miguel P. Soares 1 ,2 * Immunobiology Research Center, Department of Surgery, and ‡ Division of Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; and † Instituto Gulbenkian de Ciência, Oeiras, Portugal 2 Correspondence: Gulbenkian Institute of Science, Inflammation laboratory, Rua da Quinta Grande, 6-2780 Oeiras, Portugal. E-mail: mpsoares@igc.gulbenkian.pt <h3>SPECIFIC AIMS</h3> Heme oxygenase-1 (HO-1), which degrades heme into three products (carbon monoxide, free iron, and biliverdin), plays a protective role in many models of disease via its anti-inflammatory, anti-apoptotic, and anti-proliferative actions. Expression of HO-1 suppresses immune responses and prolongs the survival of transplanted organs; however, the mechanism underlying these effects is not clear. We tested the hypothesis that HO-1 modulates the activation of T cells in a manner that helps sustain the survival of transplanted organs. We found that HO-1 exerts potent immunosuppressive effects in alloreactive T cells, preventing cells from mediating the
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Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells
McDaid, James; Yamashita, Kenichiro; Chora, Angelo; Öllinger, Robert; Strom, Terry B.; Li, Xian C.; Bach, Fritz H.; Soares, Miguel P.
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, Volume 19 (3): 458
Fed of American Socs for Experimental Biology – Mar 1, 2005
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