Exercise-induced promotion of hippocampal cell proliferation requires β-endorphin M. Koehl * ,1 ,2 , P. Meerlo † ,1 , D. Gonzales * , A. Rontal ‡ , F. W. Turek ‡ and D. N. Abrous * * INSERM, U862 and University of Bordeaux, Bordeaux, France; † Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands; and ‡ Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, USA 2 Correspondence: Centre de Recherche INSERM U862, Physiopathologie de la Plasticité Neuronale, 146 Rue Léo Saignat, 33077 Bordeaux Cedex, France. E-mail: koehl@bordeaux.inserm.fr Adult hippocampal neurogenesis is influenced by a variety of stimuli, including exercise, but the mechanisms by which running affects neurogenesis are not yet fully understood. Because β-endorphin, which is released in response to exercise, increases cell proliferation in vitro , we hypothesized that it could exert a similar effect in vivo and mediate the stimulatory effects of running on neurogenesis. We thus analyzed the effects of voluntary wheel-running on adult neurogenesis (proliferation, differentiation, survival/death) in wild-type and β-endorphin-deficient mice. In wild-type mice, exercise promoted cell proliferation evaluated by sacrificing animals 24 h after the last 5-bromo-2'-deoxyuridine (BrdU) pulse and by using endogenous cell cycle markers (Ki67 and pH 3 ). This was accompanied by an increased survival of 4-wk-old BrdU-labeled cells, leading to a net increase of neurogenesis. β-Endorphin deficiency had no effect in sedentary mice, but it completely blocked the running-induced increase in cell proliferation; this blockade was accompanied by an increased survival of 4-wk-old cells and a decreased cell death. Altogether, adult neurogenesis was increased in response to exercise in knockout mice. We conclude that β-endorphin released during running is a key factor for exercise-induced cell proliferation and that a homeostatic balance may regulate the final number of new neurons. Koehl, M., Meerlo, P., Gonzales, D., Rontal, A., Turek, F. W., Abrous, D. N. Exercise-induced promotion of hippocampal cell proliferation requires β-endorphin. Key Words: running • opioids • cell survival • adult neurogenesis • homeostatic balance
End of preview. The entire article is 10 pages. To view the full-text, please rent this article to continue.
/lp/fed-of-american-socs-for-experimental-biology/exercise-induced-promotion-of-hippocampal-cell-proliferation-requires-QfhDi1se0b
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Exercise-induced promotion of hippocampal cell proliferation requires β-endorphin
Koehl, M.; Meerlo, P.; Gonzales, D.; Rontal, A.; Turek, F. W.; Abrous, D. N.
Follow The FASEB Journal
, Volume 22 (7): 2253
Fed of American Socs for Experimental Biology – Jul 1, 2008
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
