Evidence for a functional role of the second C5a receptor C5L2 Hongwei Gao * , Thomas A. Neff * , Ren-Feng Guo * , Cecilia L. Speyer * , J. Vidya Sarma * , Scott Tomlins * , Yunfang Man * , Niels C. Riedemann † , L. Marco Hoesel * , Ellen Younkin * , Firas S. Zetoune * and Peter A. Ward * ,1 * Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA; and † Department of Trauma Surgery, University of Hannover Medical School, Hannover, Germany 1 Correspondence: Department of Pathology, University of Michigan Medical School, 1301 Catherine Rd., Ann Arbor, MI 48109-0602, USA. E-mail: pward@umich.edu <h3>SPECIFIC AIMS</h3> Recent research demonstrates that C5a/C5aR play an important role for the development of sepsis and harmful impairment of crucial innate-immune functions. The aim of current report was to investigate the presence and regulation of the second C5a receptor, C5L2, the putative "default" or nonsignaling receptor for C5a on neutrophils and various organs during sepsis (after cecal ligation and puncture) and to evaluate role for C5L2 in balancing the biological responses to C5a. <h3>PRINCIPAL FINDINGS</h3> <h3>1. 5'-RACE PCR, cDNA cloning and sequence comparison of the
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Evidence for a functional role of the second C5a receptor C5L2
Gao, Hongwei; Neff, Thomas A.; Guo, Ren-Feng; Speyer, Cecilia L.; Sarma, J. Vidya; Tomlins, Scott; Man, Yunfang; Riedemann, Niels C.; Hoesel, L. Marco; Younkin, Ellen; Zetoune, Firas S.; Ward, Peter A.
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, Volume 19 (8): 1003
Fed of American Socs for Experimental Biology – Jun 1, 2005
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