Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2 OREN M. TEPPER 1 , MATTHEW J. CALLAGHAN 1 , EDWARD I. CHANG, ROBERT D. GALIANO, KIRIT A. BHATT, SAMUEL BAHARESTANI, JEAN GAN, BRUCE SIMON, RICHARD A. HOPPER, JAMIE P. LEVINE and GEOFFREY C. GURTNER 2 New York University Medical Center, Institute of Reconstructive Plastic Surgery, New York, New York, USA 2 Correspondence: New York University Medical Center, Institute of Reconstructive Plastic Surgery, TH-169, 550 First Ave., New York, NY 10016, USA. E-mail: geoffrey.gurtner@med.nyu.edu <h3>SPECIFIC AIMS</h3> Pulsed electromagnetic fields (PEMF) have been shown to be clinically beneficial in repairing bones and other tissues, but the mechanism of action is unclear. The present study examined the effect of PEMF on angiogenesis in order to elucidate a potential mechanism for its therapeutic effect. <h3>PRINCIPAL FINDINGS</h3> <h3>1. PEMF induces endothelial tubule formation</h3> Endothelial cell tubulization is critical to the process of angiogenesis. The effects of PEMF on endothelial tubule formation were assessed using a gelatin microcarrier assay that allowed endothelial cells to tubulize from a single focus, which could subsequently be quantified. In PEMF, a several fold increase in tubulization of one and two diameters was seen
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Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2
TEPPER, OREN M.; CALLAGHAN, MATTHEW J.; CHANG, EDWARD I.; GALIANO, ROBERT D.; BHATT, KIRIT A.; BAHARESTANI, SAMUEL; GAN, JEAN; SIMON, BRUCE; HOPPER, RICHARD A.; LEVINE, JAMIE P.; GURTNER, GEOFFREY C.
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, Volume 18 (11): 1231
Fed of American Socs for Experimental Biology – Aug 1, 2004
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