Electrical inhibition of lens epithelial cell proliferation: an additional factor in secondary cataract? Entong Wang * , Brian Reid * , Noemi Lois † , John V. Forrester † , Colin D. McCaig * and Min Zhao * ,1 Departments of * Biomedical Sciences and † Ophthalmology, University of Aberdeen, Aberdeen, U.K. 1 Corresponding author: Biomedical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK. E-mail: m.zhao@abdn.ac.uk <h3>SPECIFIC AIMS</h3> Cataract, the most common form of blindness, is treatable by surgery. Unfortunately, many patients develop the complication of posterior capsule opacification (PCO), or secondary cataract. This arises from stimulated cell growth within the lens capsule and can greatly impair vision. The mechanisms underlying this aberrant growth of lens cells after surgery are not fully understood. We propose and show that cataract surgery might remove an important inhibitory factor for lens cell growth: electric fields. The lens generates a unique pattern of electric currents; we show that cutting and removing part of the anterior capsule as in cataract surgery significantly decreases the equatorial electric current. In addition, application of electric fields to human lens epithelial cells (LEC) in culture inhibits cell proliferation. We set out to test the hypothesis that
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Electrical inhibition of lens epithelial cell proliferation: an additional factor in secondary cataract?
Wang, Entong; Reid, Brian; Lois, Noemi; Forrester, John V.; McCaig, Colin D.; Zhao, Min
Follow The FASEB Journal
, Volume 19 (7): 842
Fed of American Socs for Experimental Biology – May 1, 2005
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