Effects of Ca 2+ sensing receptor activation in the growth plate 1 SHUFANG WU * , TERESA PALESE ‡ , OM PRAKASH MISHRA † , MARIA DELIVORIA-PAPADOPOULOS † and FRANCESCO DE LUCA * ,2 * Section of Endocrinology and Diabetes and † Neonatal Medicine, Department of Pediatrics, Drexel University College of Medicine, St. Christopher’s Hospital for Children, Philadelphia, Pennsylvania, USA; and ‡ Division of Pediatric Endocrinology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA 2 Correspondence: St. Christopher’s Hospital for Children, Erie Ave. at Front St., Philadelphia, PA 19134, USA. E-mail: francesco.deluca@drexel.edu <h3>SPECIFIC AIMS</h3> Regarding longitudinal bone growth, it has been assumed that calcium ion is important exclusively for cartilage and bone matrix mineralization. Based on previous evidence, we hypothesized that calcium ion, through the activation of Ca 2+ sensing receptor (CaR) in the growth plate, regulates proliferation and hypertrophy/differentiation of growth plate chondrocytes and, in turn, the rate of longitudinal bone growth. <h3>PRINCIPAL FINDINGS</h3> <h3>1. CaR activation in the growth plate stimulates longitudinal bone growth</h3> Fetal rat metatarsal bones (20 days postconception) were cultured for 7 days in serum-free medium containing 0, 0.1, 0.3, or 1 mM Ca 2+ ( n =14–23/group). Ca
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Effects of Ca2+ sensing receptor activation in the growth plate
WU, SHUFANG; PALESE, TERESA; MISHRA, OM PRAKASH; DELIVORIA-PAPADOPOULOS, MARIA; DE LUCA, FRANCESCO
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, Volume 18 (1): 143
Fed of American Socs for Experimental Biology – Jan 1, 2004
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