Editorial: Leukocyte trafficking and matrix metalloproteinase-8 in obliterative bronchiolitis Hartmut Grasemann and Felix Ratjen 1 Division of Respiratory Medicine, Department of Paediatrics, and Program in Physiology and Experimental Medicine, Research Institute, The Hospital For Sick Children, University of Toronto, Toronto, Canada 1. Correspondence: The Hospital For Sick Children, 555 University Ave., Toronto, ON, Canada M5G 1X8. E-mail: felix.ratjen@sickkids.ca adhesion migration Airway inflammation with recruitment of neutrophils into the airway lumen is a characteristic of chronic obstructive lung diseases including cystic fibrosis, bronchiectasis, chronic bronchitis, chronic obstructive pulmonary disease, and obliterative bronchiolitis and is also seen in some patients with asthma. It is known that transmigrating neutrophils release soluble mediators including proteases, cationic peptides, and reactive oxygen species, which improve tissue permeability [ 1 ] . Neutrophil elastase, the predominant protease in neutrophil-dominated inflammatory airway diseases is thought to cause damage to the lung by degrading structural proteins such as elastin, collagen, fibronectin, and proteoglycans [ 2 ] . Among other mediators of tissue injury in inflammatory and immune processes are the MMPs, a group of enzymes that are produced and released by neutrophils but also by other cells including alveolar macrophages. In addition to mediating tissue injury, MMPs
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Editorial: Leukocyte trafficking and matrix metalloproteinase-8 in obliterative bronchiolitis
Grasemann, Hartmut; Ratjen, Felix
Follow Journal of Leukocyte Biology
, Volume 87 (1): 23
Fed of American Socs for Experimental Biology – Jan 1, 2010
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