Ectopic expression of IGF-I and Shh by skeletal muscle inhibits disuse-mediated skeletal muscle atrophy and bone osteopenia in vivo 1 MOHAMMED BORHAN ALZGHOUL, DAVE GERRARD † , BRUCE A. WATKINS § and KEVIN HANNON * ,2 Basic Veterinary Sciences, School of Veterinary Medicine, Irbid-Jordan; * Departments of Basic Medical Sciences, School of Veterinary Medicine, † Department of Animal Sciences and § Department of Food Sciences, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, Indiana, USA 2 Correspondence: Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA. E-mail: kmh@vet.purdue.edu <h3>SPECIFIC AIM</h3> The specific aim of our study was to identify anabolic proteins that can inhibit disuse atrophy in skeletal muscle and bone when electroporated and ectopically expressed in skeletal muscle in vivo. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Electroporation into and ectopic expression of IGF-I and/or Shh in gastrocnemius/soleus muscles of 15-wk-old mice resulted in significantly enlarged muscle fibers, increased muscle mass, increased tibia/fibula bone mineral density (BMD), and bone mineral content (BMC) 7, 14, and 30 days post-DNA injection</h3> IGF-I, Shh, or IGF-I+Shh expression plasmids were injected and electroporated into the gastrocnemius/soleus muscles of 15-wk-old mice. Compared with the contralateral control injected
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Ectopic expression of IGF-I and Shh by skeletal muscle inhibits disuse-mediated skeletal muscle atrophy and bone osteopenia in vivo
ALZGHOUL, MOHAMMED BORHAN; GERRARD, DAVE; WATKINS, BRUCE A.; HANNON, KEVIN
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, Volume 18 (1): 221
Fed of American Socs for Experimental Biology – Jan 1, 2004
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