Early-onset calorie restriction conserves fiber number in aging rat skeletal muscle 1 SUSAN H. McKIERNAN, ENTELA BUA, JENNIFER McGORRAY and JUDD AIKEN 2 Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA 2 Correspondence: Department of Animal Health and Biomedical Sciences, University of Wisconsin, 1656 Linden Dr., Madison, WI 53706, USA. E-mail: aiken@svm.vetmed.wisc.edu <h3>SPECIFIC AIMS</h3> Sarcopenia is the age-related loss of muscle mass and function. It is a complicated multifactorial process with no clear etiology. Muscle mass loss with age has a significant impact on the physiological and social well-being of the aged. Calorie restriction (CR) has been shown to retard many of the deleterious effects of aging in rodent and nonhuman primate models. We hypothesize that CR would significantly affect progressive muscle mass loss with age. The specific aims of this work were to examine the effects of aging on skeletal muscle in a long-lived hybrid rat strain by analysis of muscle weight, muscle fiber number, and muscle fiber atrophy using three different muscles and to determine the influence of early-onset CR on that process in young, intermediate aged, and very aged animals. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Significant sarcopenic changes
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Early-onset calorie restriction conserves fiber number in aging rat skeletal muscle
McKIERNAN, SUSAN H.; BUA, ENTELA; McGORRAY, JENNIFER; AIKEN, JUDD
Follow The FASEB Journal
, Volume 18 (3): 580
Fed of American Socs for Experimental Biology – Mar 1, 2004
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