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Journals The FASEB Journal Volume 18 Issue 12

Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: Involvement of the sphingolipid signaling pathways RICCARDA GRANATA, LETIZIA TROVATO, GIOVANNI GARBARINO, MARINA TALIANO, RENATA PONTI * , GIUSY SALA † , RICCARDO GHIDONI † and EZIO GHIGO 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, * Section of Clinics and Oncological Dermatology, University of Turin, Turin, Italy; and † Laboratory of Biochemistry and Molecular Biology, San Paolo University Hospital, University of Milan, Milan, Italy 1 Correspondence: Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, C.so Dogliotti 14-10126 Turin, Italy. E-Mail: ezio.ghigo@unito.it <h3>SPECIFIC AIMS</h3> Our aims were to 1) establish the role of IGFBP-3 on primary human umbilical vein endothelial cell (HUVEC) apoptosis and survival; 2) determine the role of sphingolipid signaling in mediating IGFBP-3 effects, providing mechanistic insight into IGFBP-3 function in HUVEC; 3) assess IGFBP-3 induction of IGF-I expression and IGF-IR signaling; and 4) evaluate IGFBP-3 influence on endothelial cell (EC) motility. <h3>PRINCIPAL FINDINGS</h3> <h3>1. IGFBP-3 enhances the apoptotic effect of doxorubicin and reduces apoptosis induced by serum starvation</h3> To investigate the effect of IGFBP-3 on apoptosis induced by doxorubicin and serum starvation, HUVEC were preincubated for 1 h with

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Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: Involvement of the sphingolipid signaling pathways

GRANATA, RICCARDA; TROVATO, LETIZIA; GARBARINO, GIOVANNI; TALIANO, MARINA; PONTI, RENATA; SALA, GIUSY; GHIDONI, RICCARDO; GHIGO, EZIO
The FASEB Journal , Volume 18 (12): 1456
Fed of American Socs for Experimental Biology – Sep 1, 2004

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