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Journals The FASEB Journal Volume 20 Issue 2

Diverse membrane-associated proteins contain a novel SMP domain Ian Lee * ,1 and Wanjin Hong * ,† * Computational Molecular Biology Programme and † Membrane Biology Lab, Institute of Molecular and Cell Biology, Proteos, Singapore 1 Correspondence: Computational Molecular Biology Programme, Institute of Molecular and Cell Biology, 61 Biopolis Dr., Proteos, Singapore (138673). E-mail: leehh@imcb.a-star.edu.sg We have analyzed the sequence of a mitochondrial integral membrane protein, Mdm12, and found that it forms the prototype for a novel domain, designated the SMP domain, that is common to an extended family of membrane-associated proteins. Comprehensive sequence searches using protein alignment models of SMP proteins were cross-validated by statistical resampling; providing strong support for these relationships. No consensus of 3-dimensional structure was reached upon threading sequences through known folds. SMP proteins are widespread amongst eukaryotic species with a particular enrichment in plants and features suggestive of species-specific functional variations. Members of 2 SMP families, the mitochore and tricalbin proteins, are essential components of protein complexes involved in mitochondrial inheritance and receptor endocytosis while a third SMP protein family, HT008, is associated with the Rvs161-Rvs167 complex, a known regulator of sphingolipid metabolism. In addition, HT008 and PDZK8 SMP proteins possess additional protein-protein interaction domains in domain architectures that are typical of protein scaffolds and adaptors. We therefore predict that the SMP domain is an important link between these distinct membrane-associated proteins and a key regulatory hub for unidentified global regulators.—Lee, I., Hong, W. Diverse membrane-associated proteins contain a novel SMP domain. Key Words: PROBE • chaperones • signaling • eukaryotic • complexes

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Diverse membrane-associated proteins contain a novel SMP domain

Lee, Ian; Hong, Wanjin
The FASEB Journal , Volume 20 (2): 202
Fed of American Socs for Experimental Biology – Feb 1, 2006

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