Enter a sentence, or cut and paste a paragraph

Refine

Refine

Refine to these subject areas:

  • Select All | Select None

Advanced Filters »

Refine

  • Advanced Filters:

  • to

  • Specific Data Sources:

    All Edit

    Select All  |  Select None

Reset filters

Journals The FASEB Journal June 2009

Bookmark

Distinctive roles of different {beta}-amyloid 42 aggregates in modulation of synaptic functions

To view this document, you will need to have Adobe Flash Player 10 or above installed.
Please click here to install.

To determine how endogenously secreted β-amyloid 42 (Aβ42) aggregates regulate synaptic functions, we examined effects of Aβ42 at the neuromuscular junction of Drosophila larvae. Voltage-clamp recordings of synaptic transmission and optical analysis of vesicle recycling at presynaptic terminals show that expression of Aβ42 in neurons leads to a reduction of neurotransmitter release. However, expression of Aβ42 in postsynaptic muscle cells enhanced neurotransmitter release. Both effects are neutralized by Aβ antibody, suggesting a role for secreted Aβ42 peptides. Application of exogenously prepared Aβ42 oligomers leads to a reduction in synaptic responses, whereas mixed Aβ42 aggregates with mainly fibrils elicit an opposite effect by increasing synaptic transmission. Further analysis of long-term depression (LTD) confirms differential effects of different Aβ42 aggregates. Taken together, our data suggest that Aβ42 is secreted from neurons primarily as oligomers that inhibit neurotransmitter release and exert no effect on LTD. Whereas larger-sized aggregates, possibly fibrils, are major components secreted from muscle cells, which enhance synaptic transmission and LTD. Thus, different types of cells may secrete distinct forms of Aβ42 aggregates, leading to different modulation of synaptic functions.—Chiang, H.-C., Iijima, K., Hakker, I., Zhong, Y. Distinctive roles of different β-amyloid 42 aggregates in modulation of synaptic functions.

To view this document, you will need to have Adobe Flash Player 10 or above installed.
Please click here to install.

This is a preview. The total pages displayed will be limited.

Rent for $0.99 FREE

Login

It seems like you have an account, please login to rent this article

Forgot your password?

Don't have an account yet? Sign up now!

To view the full-text of this article, sign up for a free DeepDyve account below.

A free Basic account also comes with
3 free rentals to help get you started.

It seems like you have an account, please login to rent this article

Just 30 seconds to go! Please check your inbox for a confirmation email to activate your account, then start using your 3 FREE rentals.

Learn more Existing user? Login here

Article Details
Chiang, Hsueh-Cheng; Iijima, Koichi; Hakker, Inessa; Zhong, Yi
The FASEB Journal , Volume 23 (6): 1969
Fed of American Socs for Experimental Biology – Jun 1, 2009
More Info

More Like This Article

View All dataSource[]=aspet&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imedpub&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=oxford&dataSource[]=pnas&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=pct

Browse: Subject Areas | Journals | Publishers

Bookmark an Article

To bookmark an article, please log in first, or sign up for a DeepDyve account if you don't already have one.

OK

Subscribe to Journal Email Alerts

To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don't already have one.

OK