Discovery in the lab: Plato’s paradox and Delbrück’s principle of limited sloppiness Frederick Grinnell 1 Department of Cell Biology, University of Texas Southwestern Medical School, Dallas, Texas, USA 1 Correspondence: Department of Cell Biology, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX 75390-9039, USA. E-mail: frederick.grinnell@utsouthwestern.edu towards the beginning of his book The Logic of Scientific Discovery , Sir Karl Popper reminds readers that there is no logic to how discoveries begin. The question how it happens that a new idea occurs to a man—whether it is a musical theme, a dramatic conflict, or a scientific theory—may be of great interest to empirical psychology; but it is irrelevant to the logical analysis of scientific knowledge. This latter is concerned … only with questions of justification or validity (1) ⇓ . In short, the scientific method is a method to justify and validate new ideas, not a method by which new ideas can be generated. However, for those of us practicing science, generating new ideas (novelty) is central to what we hope to accomplish. We aim for new-search not re-search . It is new-search that advances our understanding of how the world works. Although in
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