Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo Katharina Mahn * , Consuelo Borrás § , Greg A. Knock ‡ , Paul Taylor † , Imran Y. Khan † , David Sugden † , Lucilla Poston † , Jeremy P. T. Ward ‡ , Richard M. Sharpe || , Jose Viña § , Philip I. Aaronson ‡ and Giovanni E. Mann * ,1 * Cardiovascular Division, † Reproductive Health, Endocrinology and Development Division, ‡ Asthma, Allergy and Lung Biology Division, School of Biomedical and Health Sciences and School of Medicine, King’s College London, London, UK; § Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia, Valencia, Spain; and || Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, Scotland, UK 1 Correspondence: Cardiovascular Division, School of Biomedical and Health Sciences, King’s College London, Guy’s Campus, London SE1 1UL, UK. E-mail: giovanni.mann@kcl.ac.uk <h3>SPECIFIC AIMS</h3> The cardiovascular risks associated with hormone replacement therapy in postmenopausal women have precipitated a search for alternative estrogen receptor modulators. Genistein, a major isoflavone in soy protein, binds to estrogen receptor ß (ERß) with much higher affinity than
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Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo
Mahn, Katharina; Borrás, Consuelo; Knock, Greg A.; Taylor, Paul; Khan, Imran Y.; Sugden, David; Poston, Lucilla; Ward, Jeremy P. T.; Sharpe, Richard M.; Viña, Jose; Aaronson, Philip I.; Mann, Giovanni E.
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, Volume 19 (12): 1755
Fed of American Socs for Experimental Biology – Oct 1, 2005
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