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Journals Journal of Leukocyte Biology November 2009

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Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?

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This year, we celebrate the 40th birthday of the first landing of humans on the moon. By 2020, astronauts should return to the lunar surface and establish an outpost there that will provide a technical basis for future manned missions to Mars. This paper summarizes major constraints associated with a trip to Mars, presents immunological hazards associated with this type of mission, and shows that our current understanding of the immunosuppressive effects of spaceflight is limited. Weakening of the immune system associated with spaceflight is therefore an area that should be considered more thoroughly before we undertake prolonged space voyages. Key Words: microgravity • deep-space mission • immune depression • stress Related Article Immune system dysregulation during spaceflight: clinical risk for exploration-class missions Brian Crucian and Clarence Sams J. Leukoc. Biol. 2009 86: 1017-1018. Full Text PDF

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