ClotBusters!! Discovery of Thrombolytic Therapy for Treating Heart Attack & Stroke Cathryn Delude <h2>A Convergence of Pathways</h2> What do the search for antibiotics in the 1930s, the discovery of the double helix in the 1950s, and an extremely aggressive case of melanoma skin cancer in the 1970s have in common? They all contributed a piece of the puzzle to a breakthrough treatment for heart attacks and the most common form of stroke. <h3>View larger version</h3> (54K): In this window In a new window COVER IMAGE: The development of thrombolytics ("clot busters") to treat heart attack and stroke followed a complex pathway of basic research and clinical observation Natural clot busting agents from human blood vessels leeches vampire bat saliva and bacteria all played a role in helping scientists understand how to harness the power of thrombolytics to save lives Cover design by Corporate Press photos courtesy of Science Photo Library Photo Researchers Inc and the Organization for Bat Conservation That treatment, a class of "clot busting drugs" called thrombolytics, has saved untold lives. Yet as in so much of science, the introduction of thrombolytics took a long, circuitous route, with both head-scratching bewilderment and "aha!" moments along the
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