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Journals The FASEB Journal April 2009

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Cell sex: a new look at cell fate studies

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Cell death processes have been widely investigated in recent years in order to elucidate the different pathways involved in the complex machinery implicated in determining cell fate. Different forms of cell death have been described: Apart from the classical form of death known as necrosis, a well-characterized traumatic injury of the cell, several additional forms of cell death have been identified. Of these, apoptosis has been characterized in the greatest detail. Defects in the mechanisms of cell demise (that is, an excess of or decrease in apoptosis) have been associated with the pathogenesis of a number of human diseases. Here we review some new aspects derived from recent insights into this field, particularly the hypothesis that cells of males and females could display several different features, including those determining their fate.—Maselli, A., Matarrese, P., Straface, E., Canu, S., Franconi, F., Malorni, W. Cell sex: a new look at cell fate studies.

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Article Details
Maselli, Angela; Matarrese, Paola; Straface, Elisabetta; Canu, Silvia; Franconi, Flavia; Malorni, Walter
The FASEB Journal , Volume 23 (4): 978
Fed of American Socs for Experimental Biology – Apr 1, 2009
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