Calixarene derivative as a tool for highly sensitive detection and oriented immobilization of proteins in a microarray format through noncovalent molecular interaction Sang Wook Oh * , Jung Dae Moon * , Hyo Jin Lim * , Sang Yeol Park * , Taisun Kim † , JaeBum Park † , Moon Hi Han ‡ , Michael Snyder § and Eui Yul Choi * ,|| ,1 * BodiTech Med Inc., Chuncheon, Korea; † Department of Chemistry, Hallym University, Chuncheon, Korea; ‡ Proteogen Inc., Chuncheon, Korea; § Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, USA; and || Department of Genetic Engineering, Hallym University, Chuncheon, Korea 1 Correspondence: Department of Genetic Engineering, Hallym University, Chuncheon, Korea 200-702. E-mail: euichoi@hallym.ac.kr <h3>SPECIFIC AIMS</h3> We characterized the properties of the Calixarene derivatives as biolinker molecules in immobilization of proteins, compared the sensitivity and the specificity of Calixcrown with those of five other protein attachment agents, and applied Calixcrown chip to analyze samples found in clinical practices. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Calixcrown chip shows a superior sensitivity and a much lower detection limit than those chips prepared by other methods</h3> We employed a sandwich immunoassay for detection of specific interaction between
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Calixarene derivative as a tool for highly sensitive detection and oriented immobilization of proteins in a microarray format through noncovalent molecular interaction
Oh, Sang Wook; Moon, Jung Dae; Lim, Hyo Jin; Park, Sang Yeol; Kim, Taisun; Park, JaeBum; Han, Moon Hi; Snyder, Michael; Choi, Eui Yul
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, Volume 19 (10): 1335
Fed of American Socs for Experimental Biology – Aug 1, 2005
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