Bubbles, Babies and Biology: The Story of Surfactant Sylvia Wrobel, Ph.D. <h2>Second Breath: A medical mystery solved</h2> Before scientists and clinicians, working together, discovered the existence of lung surfactant and then figured out how to overcome its absence in the lungs of premature infants, more than 10,000 newborns in the United States died each year struggling for breath. No one understood why. Another 15,000 were affected by the same disease each year but recovered, as mysteriously as the others had died. In the 1950s and 1960s, this respiratory disease, misleadingly named hyaline membrane disease, was the nation's most common cause of infant death (Figure 1 ). Its most visible victim was the infant son of President John and Jacquelyn Kennedy, Patrick Bouvier Kennedy, who died in August 1963, two days after he was born five and a half weeks prematurely. <h3>View larger version</h3> (91K): In this window In a new window Figure 8. The discovery of surfactant began a basic and clinical research partnership that resulted in a dramatic decline in deaths of premature infants from respiratory distress syndrome. The story of surfactant is an excellent example of a problem identified in patients, elucidated in the lab through
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Bubbles, Babies and Biology: The Story of Surfactant
Wrobel, Sylvia
Follow The FASEB Journal
, Volume 18 (13): 1624e
Fed of American Socs for Experimental Biology – Oct 1, 2004
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