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Journals The FASEB Journal Volume 21 Issue 14

Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama, USA ABSTRACT The pluripotent nature of mesenchymal stem cells (MSC) widens their potential for tissue regeneration and as vehicles for cell therapy in molecular medicine. Although the MSC are relatively easier to obtain and propagate in culture, a major impediment remains in their engraftment to target tissues on autologous transfer. We report here that transient, ectopic expression of 4 integrin (CD49d) on MSC greatly increases bone homing in an immunocompetent mouse model. Heterodimerization of the 4 integrin with endogenous 1 integrin (CD29) was confirmed to influence this targeting. In addition to retaining their stem cell property, the engrafted MSC were also found to form osteoblasts and osteocytes in the growth plate of recipient mouse limb bones (femur/tibia) in vivo. These findings provide evidence for a novel strategy to achieve bone homing of genetically engineered MSC, which may broadly benefit in targeted therapies for osteopenic bone defects and cancer bone metastasis.— Kumar, S., Ponnazhagan, S. Bone homing of mesenchymal stem cells by ectopic 4 integrin expression. FASEB J. 21, 3917–3927 (2007) Key Words: tissue regeneration cell therapy bone targeting The bone marrow-derived pluripotent mesenchymal stem cells (MSC) have

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Bone homing of mesenchymal stem cells by ectopic α4 integrin expression

Sanjay Kumar and Selvarangan Ponnazhagan
The FASEB Journal , Volume 21 (14): 3917
Fed of American Socs for Experimental Biology – Dec 1, 2007

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