Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats Sophie Lanone * , 1 , Sébastien Bloc * , 1 , Roberta Foresti † , Abdelhamid Almolki * , Camille Taillé * , Jacques Callebert ‡ , Marc Conti § , Delphine Goven * , Michel Aubier * , Bertrand Dureuil ‘||‘ , Jamel El-Benna * , Roberto Motterlini † and Jorge Boczkowski * ,2 * INSERM U 700 and U 683, Faculté de Médecine Xavier Bichat, Université Paris VII, Paris, France; † Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK; ‡ Service de Biochimie, Hôpital Lariboisière, Université Paris VII, Paris, France; § Service de Biochimie, Hôpital du Kremlin Bicêtre, Université Paris XI, Paris, France; and ‘|| ||Département d’Anesthésie- Réanimation, Hôpital Charles Nicole, Rouen, France 2 Correspondence: INSERM U700, Faculté X. Bichat, BP416, Paris 75870, France. E-mail: jbb2@bichat.inserm.fr <h3>SPECIFIC AIMS</h3> This study is devoted to the investigation of a potential protective role for bilirubin, one of the products of heme degradation by the enzyme heme oxygenase, in endotoxic shock. The rationale is that the antioxidant and cytoprotective properties of bilirubin could protect
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Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats
Lanone, Sophie; Bloc, Sébastien; Foresti, Roberta; Almolki, Abdelhamid; Taillé, Camille; Callebert, Jacques; Conti, Marc; Goven, Delphine; Aubier, Michel; Dureuil, Bertrand; El-Benna, Jamel; Motterlini, Roberto; Boczkowski, Jorge
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, Volume 19 (13): 1890
Fed of American Socs for Experimental Biology – Nov 1, 2005
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