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Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients Eva Untersmayr * , 1 , Noémi Bakos # , 1 , Isabella Schöll * , Michael Kundi ‡ , Franziska Roth-Walter * , Krisztina Szalai * , Angelika B. Riemer * , Hendrik J. Ankersmit § , Otto Scheiner * , George Boltz-Nitulescu * and Erika Jensen-Jarolim * ,2 * Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria; # Department of Dermatology, Hetényi Géza Hospital, Szolnok, Hungary; and ‡ Center for Public Health, and § Department of CT-Surgery, Medical University of Vienna, Vienna, Austria 2 Correspondence: Center of Physiology and Pathophysiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. E-mail: erika.jensen-jarolim@meduniwien.ac.at <h3>SPECIFIC AIMS</h3> Food allergens that are able to sensitize via the gastrointestinal tract are postulated to be digestion stable. We have observed that dietary proteins lead to allergic reactions in BALB/c mice only when their B cell epitopes are stabilized. Strikingly, some typical food allergens like fish, shrimp, and potato are easily degraded when subjected to simulated gastric fluid assays. Our consequent hypothesis was that proteins might exhibit allergenic capacity not only when digestion resistant, but also when simply surviving the

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Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients

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