Angiogenesis in an in vivo model of adipose tissue development 1 JAAP G. NEELS, TERRI THINNES and DAVID J. LOSKUTOFF 2 The Scripps Research Institute, Department of Cell Biology, Division of Vascular Biology, La Jolla, California, USA 2 Correspondence: The Scripps Research Institute, Department of Cell Biology, Division of Vascular Biology, 10550 N. Torrey Pines Road, VB-3, La Jolla, CA 92037, USA. E-mail: loskutof@scripps.edu <h3>SPECIFIC AIMS</h3> Little is known about angiogenesis in adipose tissue, primarily because of the absence of reliable model systems. The general aim of these studies was to determine whether fat pads that develop when cultured 3T3-F442A cells are injected under the skin of nude mice form a suitable in vivo model system to study neovascularization of developing adipose tissue. One specific aim was to provide initial information about the morphology, kinetics of neovascularization, and gene expression profiles of the developing fat pads; another was to determine whether their new vasculature originated from bone marrow-derived endothelial progenitor cells or from preexisting host vessels. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Fat pads formed by 3T3-F442A cells in nude mice are highly vascularized and morphologically similar to inguinal fat</h3> Used to study adipogenesis, the 3T3-F442A in vivo fat pad model
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Angiogenesis in an in vivo model of adipose tissue development
NEELS, JAAP G.; THINNES, TERRI; LOSKUTOFF, DAVID J.
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, Volume 18 (9): 983
Fed of American Socs for Experimental Biology – Jun 1, 2004
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