Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle Daniel Cuthbertson * ,† , Kenneth Smith * ,§ , John Babraj * , Graham Leese † , Tom Waddell * , Philip Atherton * ,‡ , Henning Wackerhage * , Peter M Taylor * and Michael J Rennie * ,§ ,1 * Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland; † Department of Medicine, Ninewells Hospital and Medical School, Tayside NHS Trust, Dundee, Scotland; ‡ Department of Biological Sciences, University of Central Lancashire, Preston, UK; § University of Nottingham, School of Biomedical Sciences, Division of Clinical Physiology, Graduate Entry Medical School, City Hospital, Derby, UK 1 Correspondence: University of Nottingham, School of Biomedical Sciences, Division of Clinical Physiology, Graduate Entry Medical School, City Hospital, Derby DE22 3DT, UK. E-mail: michael.rennie@nottingham.ac.uk <h3>SPECIFIC AIMS</h3> Healthy aging is associated with wasting of skeletal muscle of unknown cause. We hypothesized that, for lack of good evidence of derangements of muscle protein turnover in the basal, post-absorptive state, the deficit in the muscle maintenance must lie elsewhere, possibly in a diminished response to amino acids, the most anabolically potent of nutrients. We aimed to test this
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Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, Daniel; Smith, Kenneth; Babraj, John; Leese, Graham; Waddell, Tom; Atherton, Philip; Wackerhage, Henning; Taylor, Peter M; Rennie, Michael J
Follow The FASEB Journal
, Volume 19 (3): 422
Fed of American Socs for Experimental Biology – Mar 1, 2005
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