Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice 1 HANS-JOACHIM ANDERS 2 , VOLKER VIELHAUER, VACLAV EIS, YVONNE LINDE, MATTHIAS KRETZLER, GUILLERMO PEREZ DE LEMA, FRANK STRUTZ * , STEFAN BAUER † , MARK RUTZ † , HERMANN WAGNER † , HERMANN-JOSEF GRÖNE ‡ and DETLEF SCHLÖNDORFF 1 Nephrological Center, Medical Policlinic, Ludwig-Maximilians-University Munich, Germany; * Department of Nephrology and Rheumatology, University Medical Center, Göttingen, Germany; † Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany; and ‡ Division of Molecular and Cellular Pathology, German Cancer Research Center, Heidelberg, Germany 2 Correspondence: Medizinische Poliklinik der LMU, Pettenkoferstr. 8a, 80336 Munich, Germany. E-mail: hjanders@med.uni-muenchen.de <h3>SPECIFIC AIMS</h3> It has been demonstrated that interaction of bacterial CpG-DNA with toll-like receptor (TLR) -9 on B cells stimulates autoantibody secretion, which might contribute to the pathogenesis of systemic lupus erythematosus. We investigated the effects of exogenous CpG-oligodeoxynucleotides (ODN) or DNA derived from Escherichia coli on systemic autoimmunity in nephritic MRL lpr/lpr mice 16–18 wk of age. <h3>PRINCIPAL FINDINGS</h3> 1. E. coli DNA and CpG-ODN increase serum DNA autoantibodies in MRL lpr/lpr mice We investigated the effects of bacterial DNA or CpG-ODN on anti-DNA IgG 2a and
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Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
ANDERS, HANS-JOACHIM; VIELHAUER, VOLKER; EIS, VACLAV; LINDE, YVONNE; KRETZLER, MATTHIAS; DE LEMA, GUILLERMO PEREZ; STRUTZ, FRANK; BAUER, STEFAN; RUTZ, MARK; WAGNER, HERMANN; GRÖNE, HERMANN-JOSEF; SCHLÖNDORFF, DETLEF
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, Volume 18 (3): 534
Fed of American Socs for Experimental Biology – Mar 1, 2004
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